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2026, 01, v.5 22-36
环境内分泌干扰物暴露与流产风险相关研究进展
基金项目(Foundation): 国家自然科学基金(22476120)
邮箱(Email): yuehuifeng@sxu.edu.cn;
DOI:
发布时间: 2026-01-02
出版时间: 2026-01-02
网络发布时间: 2026-01-02
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摘要:

流产是一种常见的妊娠并发症,其发生受遗传、内分泌、环境及生活方式等多重因素的复杂影响。其中,环境内分泌干扰物的普遍暴露,引起了人们对女性生殖健康风险的深切关注,特别是其与流产之间可能存在的关联是相关领域研究的热点问题。为此,本综述梳理了主要环境内分泌干扰物增加流产风险的流行病学证据和潜在毒理机制。结果表明,此类化学物质可通过干扰激素受体信号、影响子宫容受性建立、诱导氧化应激与细胞损伤、破坏胎盘功能以及引发表观遗传改变等多种途径,导致胚胎植入失败,并对妊娠维持产生持续不利影响。总体而言,本综述为理解环境内分泌干扰物对妊娠结局的潜在不良影响提供了系统参考,深化了相关风险认知,并指出了未来可能的研究思路。

Abstract:

Pregnancy loss is a common pregnancy complication influenced by a complex interplay of genetics, endocrine, environment, lifestyle, etc. Among these factors, the widespread exposure to environmental endocrine-disrupting chemicals(EEDs) has aroused deep concern for the potential risks to female reproductive health, the possible association between EEDs and pregnancy loss becoming a research focus in this field. Accordingly, this review systematically summarizes epidemiological evidence and potential toxicological mechanisms through which major EEDs may increase the risk of pregnancy loss. Findings indicate that these chemicals can contribute to embryo implantation failure and exert sustained adverse effects on pregnancy maintenance via multiple pathways, including interference with hormone receptor signaling, disruption of uterine receptivity establishment, induction of oxidative stress and cellular damage, impairment of placental function, and triggering of epigenetic alterations. In summary, this review provides a systematic reference for understanding the potential adverse effects of EEDs on pregnancy outcomes, deepens the understanding of associated risks, and suggests future research approach.

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(1)相对风险:指与对照组相比的风险比值。例如,相对风险为1. 97表示风险增加97%。

基本信息:

中图分类号:X503.1;R714.21

引用信息:

[1]梁晓敏,岳慧峰.环境内分泌干扰物暴露与流产风险相关研究进展[J].新兴科学和技术趋势,2026,5(01):22-36.

基金信息:

国家自然科学基金(22476120)

发布时间:

2026-01-02

出版时间:

2026-01-02

网络发布时间:

2026-01-02

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